Multimodal prospective analysis of biomarkers for Critical-Illness-Polyneuromyopathy on patients directly after ICU treatment

Multimodal prospective analysis of biomarkers for Critical-Illness-Polyneuromyopathy on patients directly after ICU treatment - CRIT-PATH_3

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012739

Enrollment

Registered

2017-07-14

Start date

2017-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G62.80 G72.80

Interventions

Group 1: Approx. 25 patients currently undergoing ICU- treatment (> 7 days ICU-stay including 3 days of ventilation) are examined by ENoG (elektroneurography), EMG (elektromyography), CCM (confocal c

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: voluntariness; written confirmed consent; adequate knowledge of German language; at least 18 years of age, = 7 days current stay on ICU incl. at least 3 days ventilation

Exclusion criteria

Exclusion criteria: < 18 years; withdrawal of agreement; employees of the researching medic or the facility that is partipicipating in this clinical research or other studies; simultaneous participation in an AMG-study; CCM: ophthalmic surgery within the last 3 months, MRI: metal implants, QST: skin disorder in area of investigation

Design outcomes

Primary

Measure	Time frame
Incidence of CIPNM (Critical-Illness-Polyneuromyopathie); frequency of abnormal parameters in ENG (elektroneurography), EMG (elektromypgraphy), CCM (confocal corneale microscopy), QST (quantitative sensory testing), MRT (Magnetic resonance imaging), skin biopsy; determination of sensitivity and specificity of individual parameters each for the three timepoints: directly, 3 and 12 month after ICU-treatment.	—

Measure

Time frame

Incidence of CIPNM (Critical-Illness-Polyneuromyopathie); frequency of abnormal parameters in ENG (elektroneurography), EMG (elektromypgraphy), CCM (confocal corneale microscopy), QST (quantitative sensory testing), MRT (Magnetic resonance imaging), skin biopsy; determination of sensitivity and specificity of individual parameters each for the three timepoints: directly, 3 and 12 month after ICU-treatment.

—

Secondary

Measure	Time frame
correlation of values of all investigations among each other	—

Countries

Germany

Contacts

Public ContactChristine Meyer-Frießem

Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum

meyer-friessem@ains-bergmannsheil.de0049234-3020

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026