L50.8 L40 L20.9
Conditions
Interventions
Group 1: No intervention. In all patients and subjects, itching is induced in non-lesional and lesional skin (in patients). For this purpose, cowhage spicules are applied to the skin and the resulting
Sponsors
Charité Campus Charité Mitte
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The subjects and patients must be 18 years or older. Subjects and patients must be able to communicate with the investigator. Subjects and patients must be able to understand the contents of the study and have to consent to participate in the study. In patients, the diagnosis of eczema, urticaria and psoriasis vulgaris must be confirmed by clinical examination and the history Existing health insurance (so that for example biopsy-related complications can be taken care of)
Exclusion criteria
Exclusion criteria: Current or previous treatment with immunosuppressants (e.g., prednisolone, ciclosporin A, methotrexate, dapsone or others) 4 weeks or 5 half-lives, whichever is longer, before the start of the study. Intake of antihistamines 5 days and leukotriene antagonists 7 days before study. Diagnosis of another skin disease associated with chronic itching, as well as chronic itching due to other diseases. Pregnant or lactating women. A history of hypersensitivity or allergy to local anesthetics (in subjects and patients in whom skin biopsy is taken). Intake of blood thinners Existing allergy to the local anesthetic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Itch intensity (VAS) in lesional skin of patients compared with non-lesional skin or healthy skin. The investigation takes place only at a time. | — |
Countries
Germany
Contacts
Public ContactHesna Gözlükaya
Klinik für Dermatologie und Allergologie Charité - Universitätsmedizin Berlin
Outcome results
None listed