Interactions of the Vascular Barrier, the Cardiopulmonary, and the Body Fluids System during Hypobaric Hypoxic Winter Confinement in Antarctica.

Interactions of the Vascular Barrier, the Cardiopulmonary, and the Body Fluids System during Hypobaric Hypoxic Winter Confinement in Antarctica. - EFIA (Edema Formation in Antarctica)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012678

Enrollment

Registered

2017-09-26

Start date

2017-10-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T70.2 R60.9

Interventions

Group 1: Chronic hypobaric hypoxia and confinement: Overwintering at the Concordia station in Antarctica in 3200 m. above sea level. Repeated measurements of: - Altitude sickness severity (Lake Louis

Serum concentrations of fragments of the vascular wall in (Glycocalyx) Group 2: Normobaric normoxia and confinement (control group): Overwintering at a research station in Antarctica at sea level. Re

Serum concentrations of fragments of the vascular wall in (Glycocalyx).

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: - Individuals assigned to a winter-over mission at the Concordia station in Antarctica (hypobaric hypoxia) - Individuals assigned to a winter-over mission at the Belgrano-II Antarctica station (normobaric normoxia) - Written informed consent of the subject

Exclusion criteria

Exclusion criteria: - Candidate refuses to participate

Design outcomes

Primary

Measure	Time frame
The difference of the averaged blood plasma concentration of nitric oxide between the group at altitude and the group at sea level is the primary outcome. Blood will be sampled on 13 time points during the winterover stay: after 2, 4 and 7 days and 2 and 4 weeks after arrival at the Station and after 2, 3, 4, 5, 6 ,8 ,10 and 12 months after arrival.	—

Secondary

Measure	Time frame
The difference of the averaged blood serum concentration of hyaluronan between the group at altitude and the group at sea level is the secondary outcome. Blood will be sampled on 13 time points during the winterover stay: after 2, 4 and 7 days and 2 and 4 weeks after arrival at the Station and after 2, 3, 4, 5, 6 ,8 ,10 and 12 months after arrival.	—

Countries

Argentina, France, Italy

Contacts

Public ContactUlrich Limper

Deutsches Zentrum für Luft- und Raumfahrt (DLR)Institut für Luft- und RaumfahrtmedizinAbteilung Kardiovaskuläre Luft- und Raumfahrtmedizin (KLM)

ulrich.limper@dlr.de022036013063

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026