F90.0
Conditions
Interventions
Group 1: Verum stimulation (tDCS) of the left dorsolateral prefrontal cortex (dLPFC, Study A) or the right inferior frontal gyrus (rIFG, Study B) for 20 minutes on 2 x 5 consecutive days (2-day break)
Sponsors
Universitätsklinikum Magdeburg
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: ADHD according to DSM-5 (all subtypes) age 10 to 18 the participant and their custodians are able and willing to give written informed assent/consent
Exclusion criteria
Exclusion criteria: IQ < 80 Birth weight < 2500 gr. Born before the 37th week of pregancy Past or present neurological diseases/brain surgery Dermatological diseases of the scalp All comorbid psychiatric disorders other than oppositional defiant disorder, conduct disorder, elimination disorders, anxiety disorders, learning disorders History of craniocerebral injury with loss of consciousness Heart disease Pregnancy Concurrent neurofeedback therapy Concurrent pharmacological treatment of ADHD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study A: Overall accuracy in an n-back task (assessing working memory), comparison of pre- vs. post-intervention (V0 vs. V11) Study B: Overall accuracy in a Flanker task (assessing inhibitory/interference control), comparison of pre- vs. post-intervention (V0 vs. V11) | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Severity of ADHD symptoms (inattention, hyperactivity/ impulsivity) (parents: ADHD rating scale) (Screening, V11, V12) (2) Study A: Reaction time and reaction time variability in an n-back task, number of omission and commission errors (V0, V11, V12) Study B: Reaction time and reaction time variability in a Flanker task, number of omission and commission errors in congruent and incongruent trials (V0, V11, V12) (3) Performance measures in neuropsychological tasks that assess impaired functions in ADHD but are different from the task presented during stimulation: accuracy and reaction times / reaction time variability in Study A: (a) a Flanker task and (b) a Continuous Performance task (CPT) and Study B: (a) an n-back working memory task and (b) a Continuous Performance task (CPT) (V0, V11, V12) (4) Functional brain related outcome measures (a) resting state EEG (V0, V11, V12): connectivity, phase coherence, Granger causality (b) event related potentials: amplitude, latency, latency variability, neuronal sources of task relevant components (c) resting state fMRI (V0, V11) (5) Quality of life (parents, child: KidScreen27) (Screening, V12) | — |
Countries
Germany, Portugal
Contacts
Public ContactKerstin Krauel
Universitätsklinikum, Kinder und Jugendpsychiatrie
Outcome results
None listed