M84.12 M84.15 M84.16
Conditions
Interventions
Group 1: Twenty-two patients developed an aseptic humeral shaft nonunion. 13 out of those 22 patients were treated using rigid LC plating with autologous cancellous bone grafting and additional applic
Sponsors
BG Unfallklinik Murnau
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients were included who were treated with humeral, femoral, and tibial shaft fracture and had developed aseptic shaft nonunion. Nonunion Treatment included stable internal Fixation in combination with autologous iliac crest bone graft or cancellous bone grafting, with or without additional application of recombinant human Bone Morphogenetic Protein rhBMP-7. No Intervention in the treatment algorithm was performed. All patients agreed and signed the “off-label” treatment of rhBMP-7. Written informed consent for anonymous evaluation of patients' data was obtained from the patients before initial revision surgery in our institution.
Exclusion criteria
Exclusion criteria: Patients with congenital forms of nonunion or skeletal immaturity as well as patients with previous or consecutive positive bacterial cultures were excluded from the study to restrict the study group to aseptic nonunion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Point of time of radiological bony healing. Data was evaluated retrospectively according to available databased radiological and clinical findings. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Differences in terms of nonunion healing. 2. Differences according to range of time between revision surgery and nonunion healing. 3. Differences in terms of complications (functional outcome). Data was evaluated retrospectively according to available databased radiological and clinical findings. | — |
Countries
Germany
Contacts
Public ContactChristian von Rüden
BG Unfallklinik Murnau
Outcome results
None listed