Risk assessment for the developing of a postoperative delirium in cardiac surgical patients on the basis of serum cholinesterase activity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012630

Enrollment

220

Registered

2017-07-14

Start date

2013-09-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F05.8

Interventions

Group 1: Investigation of choline esterase activity and development of postoperative delirium in patients undergoing cardiovascular surgery with cardio-pulmonary bypass. Preoperatively, a dementia te

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adults, consenting patients > 18 years; Cardiac surgery with or without a cardio-pulmonary bypass receiving an aortocoronary bypass or aortic valve operation; ASA I - IV

Exclusion criteria

Exclusion criteria: Absence of consent; Dementia; Failed mini mental test (MMST); Patients with Parkinson's disease; Patients with Alzheimer's disease

Design outcomes

Primary

Measure	Time frame
Correlation between the pre-/perioperative serum acetyl or butyrylcholinesterase concentration and the neuropsychological outcome of the patients. Neuropsychological outcome, ie the occurrence of a delirium, is measured on 1, 2, 3, and 5 postoperative days, using the specific delirium questionnaires Nu-DESC and ICDSC. The acetyl and butyrylcholinesterase concentrations are measured in parallel for this purpose.	—

Measure

Time frame

Correlation between the pre-/perioperative serum acetyl or butyrylcholinesterase concentration and the neuropsychological outcome of the patients. Neuropsychological outcome, ie the occurrence of a delirium, is measured on 1, 2, 3, and 5 postoperative days, using the specific delirium questionnaires Nu-DESC and ICDSC. The acetyl and butyrylcholinesterase concentrations are measured in parallel for this purpose.

—

Secondary

Measure	Time frame
Modification of serum acetyl- or butyrylcholinesterase concentrations in patients undergoing cardio-vascular surgery; preoperatively, a capillary withdrawal of blood from the fingertip or the ear lobe for the determination of the acetyl- and butyrylcholinesterase is performed, as well as immediately postoperatively on the operating day and in the further course on the first, second, third and fifth postoperative days. Influence of the cardio-pulmonary bypass on the course of acetylcholinesterase and butyrylcholinesterase activity and neuropsychological outcome of the patients. Influence of various surgical procedures (aortocoronary bypass surgery and aortic valve replacement) on cholinesterase activity.	—

Measure

Time frame

Modification of serum acetyl- or butyrylcholinesterase concentrations in patients undergoing cardio-vascular surgery; preoperatively, a capillary withdrawal of blood from the fingertip or the ear lobe for the determination of the acetyl- and butyrylcholinesterase is performed, as well as immediately postoperatively on the operating day and in the further course on the first, second, third and fifth postoperative days. Influence of the cardio-pulmonary bypass on the course of acetylcholinesterase and butyrylcholinesterase activity and neuropsychological outcome of the patients. Influence of various surgical procedures (aortocoronary bypass surgery and aortic valve replacement) on cholinesterase activity.

—

Countries

Germany

Contacts

Public ContactBritta Wolf

Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH

britta.wolf@bergmannsheil.de+49 234 302-3628

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026