Repeated MRI acquisition in healthy controls to establish longitudinal age related MR changes

Repeated MRI acquisition in healthy controls to establish longitudinal age related MR changes - WiMAk

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00012600

Enrollment

Registered

2017-08-04

Start date

2017-08-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal aging of the brain in healthy controls Healthy subjects

Interventions

Group 1: In this study, we measure various MR-parameters in healthy controls in a baseline MRI and two follow-ups at 3 and 12 months. We can then compare the longitudinal changes in healthy controls t

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: - signed informed consent form

Exclusion criteria

Exclusion criteria: - known neurological or degenerative diseases - previous brain surgery - previous brain radiotherapy - previous chemotherapy - contraindications for MRI acquisition - incidental findings identified as part of this study

Design outcomes

Primary

Measure	Time frame
Primary outcome is to quantify MR-parameter changes in the brains of healthy controls following a baseline MRI and repeated MRIs at 3 months and 12 months using image analysis techniques. These MR-parameters are quantitative MR measures T1, T2, T2* (in ms) and proton density (in percentage units relative to water), isotropic and anisotropic diffusion, metabolite concentrations (e.g. Choline, Creatine, N-acetylaspartate), as well as volumetric measurements of various brain regions.	—

Measure

Time frame

Primary outcome is to quantify MR-parameter changes in the brains of healthy controls following a baseline MRI and repeated MRIs at 3 months and 12 months using image analysis techniques. These MR-parameters are quantitative MR measures T1, T2, T2* (in ms) and proton density (in percentage units relative to water), isotropic and anisotropic diffusion, metabolite concentrations (e.g. Choline, Creatine, N-acetylaspartate), as well as volumetric measurements of various brain regions.

—

Secondary

Measure	Time frame
- using the baseline MRIs, we will determine possible correlations of MR-parameters with age - changes of MR-parameters with age after 3 months and 12 months in healthy controls will be compared to those of glioma patients	—

Countries

Germany

Contacts

Public ContactAnnett Klöber

Universitätsklinikum Dresden, Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Klinisches Studienzentrum

str.studien@uniklinikum-dresden.de0351-458 13390

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026