Investigation of cognitive reserve and epigenetic modifications in individuals with a probable neurodegenerative disease

Investigation of cognitive reserve and epigenetic modifications in individuals with a probable neurodegenerative disease - CR-EPI-ND

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012575

Enrollment

200

Registered

2017-06-07

Start date

2019-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G31.9

Interventions

Group 1: Patients with a suspected diagnosis of a neurodegenerative diseases, who are treated at the department of nuclear medicine at the University Hospital Cologne are asked to fill in questionnair

Eligibility

Sex/Gender

All

Age

55 Years to 99 Years

Inclusion criteria

Inclusion criteria: Consent can be given, Suspected diagnosis of a neurodegenerative disease

Exclusion criteria

Exclusion criteria: Contraindiciations for PET imaging

Design outcomes

Primary

Measure	Time frame
Individual proxies of the cognitive reserve will once be determined by means of different questionnaires (Lifetime Experience Questionnaire, MeDI Questionnaire, Questionnaire regarding schooling, social environment, RS-13 Resilience Questionnaire, Historical Leisure Activity Questionnaire) on the day of the routine PET examination. In addition, on the day of the routine PET examination, two peripheral blood samples will be taken, which will be assess for epigenetic changes. The acquired cognitive reserve measures and the epigenetic information will then be linked to the PET imaging parameters.	—

Measure

Time frame

Individual proxies of the cognitive reserve will once be determined by means of different questionnaires (Lifetime Experience Questionnaire, MeDI Questionnaire, Questionnaire regarding schooling, social environment, RS-13 Resilience Questionnaire, Historical Leisure Activity Questionnaire) on the day of the routine PET examination. In addition, on the day of the routine PET examination, two peripheral blood samples will be taken, which will be assess for epigenetic changes. The acquired cognitive reserve measures and the epigenetic information will then be linked to the PET imaging parameters.

—

Countries

Germany

Contacts

Public ContactMerle Hönig

Klinik und Poliklinik für Nuklearmedizin, Uniklinik Köln

merle.hoenig@uk-koeln.de022147882837

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026