I95 I95.2
Conditions
Interventions
Group 1: time period 1:
retrospective assessment of patients receiving ephedrine due to arterial hypotension during cesarean section und spinal anaesthesia.
Group 2: time period 2:
retrospective asses
Sponsors
Klinik für Anästhesie und Intensivtherapie der Philipps-Universität Marburg
Eligibility
Sex/Gender
Female
Age
16 Years to 50 Years
Inclusion criteria
Inclusion criteria: - cesarean section performed under spinal anaesthesia between July 2012 and April 2017, - arterial hypotension that required pharmacological stabilization according to the decision of the attending anesthesiologist
Exclusion criteria
Exclusion criteria: emergency section performed under general anaesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A) endpoints with respect to the parturient: symptomatic alterations of haemodynamics associated with symptoms like dizziness, nausea, vomiting, clouding of consciousness, unconsciousness, palpitation - data recording was performed retrospectively (chart review) - B) endoints with respect to the fetus/newborn: - pH in the umbilical cord - BE in the umbilical cord (BE=base excess) - data recording was performed retrospectively (chart review) - | — |
Secondary
| Measure | Time frame |
|---|---|
| A) secondary endpoint with respect to the parturient: - lowest heart rate documented - incidence of bradycardia (new definition adopted for pregnat femals undergoing cesarean section; heart rate 110 bpm) - incidence of pharmacological interventions to treat bradycardia, e.g. administration of atropine, orciprenalin, epinephrine - incidence of pharmacological interventions to treat tachycardia, e.g. administration of beta-blocker - incidence of pharmacological interventions to treat persistent hypotension, e.g. administration of a second/alternative catecholamine besides the initial treatment with Akrinor, ephedrin, or phenylephrine respectively - numbers of boluses of Akrinor/Ephedrin/phenylephrine until a mean arterial pressure of at least 70 mmHg is restored - Excessive raise of arterial blood pressure (defined as mean arterial pressure > 100 mmHg B) secondary endpoint with respect to the fetus/newborn: - incidence of acidoses (defined as pH 10 mmol) - APGAR-score 1,5,10 min after cutting the umbilical cord C) Explorative data analysis: further descriptive analyses are planned to create hypotheses, mainly focusing on efficacy and efficiency parameters, e.g. time until 10, 20, 30 percent increase of arterial blood pressure are reached. Data analysis on blood pressure will be performed with MAP (mean arterial pressure) that is provided from the automated blood pressure measurement system. If such an automated measurement is not available MAP will be calculated according to the formula: MAP = (RRsyst. + 2xRRdiast.) / 3 - data recording was performed retrospectively (chart review) | — |
Countries
Germany
Contacts
Public ContactLeopold Eberhart
Klinik für Anästhesie und Intensivtherapie der Philipps-Universität Marburg
Outcome results
None listed