E66
Conditions
Interventions
Group 1: Obese patients that fullfil the criteria for receiving a gastric-bypass surgery
Group 2: healthy, normal-weighted control group
Sponsors
Fakultät VI - Medizin und Gesundheitswissenschaften Carl-von Ossietzky Universität Oldenburg
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age: 18-60 BMI: >35kg/m2 (Obesity-Group); <25kg/m2 (Control-Group) Gender: Female Participants in the obesity group will receive RYGB operation
Exclusion criteria
Exclusion criteria: Substance abuse Smoking Psychiatric disorders (except anxiety) History of eating disorder Psychopharmacological treatment Pregnancy Claustrophobia Neurological disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Neuronal food porcessing - presentation via food-images - measured with fMRI 2. working memory - presentation with 2-back-task - measured with fMRI 3. functional connectivity - measurement at rest with fMRI All measurements will be done twice (pre-surgery and one year post-surgery) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. hormonal status (GLP-1, PYY) 2. working memory results from the 2-back-task (hits, erros, false postives) 3. questionnaire data (Freiburg Personality Inventory, structured clinical interview, questionnaire if eating behavior, Beck Depression Inventory, Behavioral Inhibtion System, Wender-Utah-rating scales, Conners' adult ADHD self-rating scales) All measurements will be done twice (pre-surgery and one year post-surgery) | — |
Countries
Germany
Contacts
Public ContactMarcel Schulze
Medizinischer Campus Universität Oldenburg Fakultät für Medizin und Gesundheitswissenschaften Universitätsklinik für Psychiatrie und Psychotherapie Karl-Jaspers-Klinik
Outcome results
None listed