Interference of experimental pain and cognition in patients suffering from chronic pain

Interference of experimental pain and cognition in patients suffering from chronic pain - RUMI

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00012448

Enrollment

180

Registered

2017-05-23

Start date

2017-05-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M54 G43

Interventions

Group 1: Patients suffering from chronic low back pain ( pain > 3 months) perform a categorization and recognition task while receiving either (1) painful stimuli at the lower back, (2) at the forehea

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Age: 18 - 80 (2) voluntary, informed study participation (3) chronic low back pain or chronic migraine (> 3 months; for migraine: attacks on > 15 days per month); healthy control subjects (matched to pain patients in age, gender, education)

Exclusion criteria

Exclusion criteria: (4) participation in other clinical trials testing medication (5) severe depression or anxiety disorder (6) pregnancy, nursing (7) medication-overuse headache (MOH) (8) other chronic pain conditions except lower back pain or migraine (esp. radicular pain, neuropathic pain) (9) intake of highly dosed opioids (10) contraindication for MR testing, e.g. • cardiac pacemaker and other magnetizable material within the body • MR-incompatible metal material • claustrophobia

Design outcomes

Primary

Measure	Time frame
mean reaction times (ms) (categorisation task) and recognition performance (d prime, recollection and familiarity parameters) for images previously presented with electrical pain stimuli (1) at the lower back (L3-L5), (2) at the forehead (V1) or (3) without additional painful stimulation; Group comparison: (1) patients suffering from chronic lower back pain, (2) patients suffering from chronic migraine and (3) healthy control subjects. interaction effects: group x condition	—

Measure

Time frame

mean reaction times (ms) (categorisation task) and recognition performance (d prime, recollection and familiarity parameters) for images previously presented with electrical pain stimuli (1) at the lower back (L3-L5), (2) at the forehead (V1) or (3) without additional painful stimulation; Group comparison: (1) patients suffering from chronic lower back pain, (2) patients suffering from chronic migraine and (3) healthy control subjects. interaction effects: group x condition

—

Secondary

Measure	Time frame
1) mean skin conductance response (amplitude, microsiemens; latency, ms) during painful stimulation and during the recognition task (for each experimental phase: main effect group, main effect stimulation, interaction group x stimulation) 2) Structural and functional predispositions (morphometry, resting state fMRI)	—

Countries

Germany

Contacts

Public ContactKatarina Forkmann

Universitätsklinik Essen AöR; Klinik für Neurologie

katarina.forkmann@uk-essen.de+49 201 723-2364

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026