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Perceptual correlate of nociceptive long-term potentation (LTP) in the greater occipital nerve (GON) and the three branches of the trigeminal nerve after electrical high frequency stimulation (HFS) of the first trigeminal branch, V1, and the GON, respectively.

Perceptual correlate of nociceptive long-term potentation (LTP) in the greater occipital nerve (GON) and the three branches of the trigeminal nerve after electrical high frequency stimulation (HFS) of the first trigeminal branch, V1, and the GON, respectively.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00012442
Enrollment
25
Registered
2017-08-24
Start date
2017-08-31
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trigeminocervical complex in healthy participants

Interventions

Group 1: Healthy subjects are to go through four sessions: 1) High frequency stimulation at V1 2) High frequency stimulation at the GON. 3) Control session without High frequency stimulation. 4) T

Sponsors

Universitätsklinikum Hamburg-Eppendorf
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Healthy subjets, that do not fulfill any exclusion critera.

Exclusion criteria

Exclusion criteria: Pain and/or headache disorders (people reporting infrequent episodic TTH are accepted as long as they have less than 12 episodes a year), 1. Generation family member with primary headache disorder, skin lesions or other dermatological disorders in the applied areas (neck and face region), men with full beard, neurological, psychiatric or other chronic disorders, whiplash or other damages to the cervical spine, pregnancy or breast feeding, misuse of alcohol or drugs, inability to speak or understand German

Design outcomes

Primary

MeasureTime frame
Perceptive pain ratings of each of the electrical stimulations, single pulses as well as high frequency stimulations. The stimulations are rated on a visual analog scale (VAS) corresponding 0 (no pain) through to 100 (worst imaginable pain) and are registered by the subject on a computer immediately after each stimulation.

Countries

Germany

Contacts

Public ContactTrine Nielsen

Institut für Systemische Neurowissenschaften

t.nielsen@uke.de040741058943

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026