Childhood Escape – Late Life Outcome (CELLO): metabolic, psychiatric, endocrinological and epigenetic consequences of escape from East Prussia in affected subjects and their offspring

Childhood Escape – Late Life Outcome (CELLO): metabolic, psychiatric, endocrinological and epigenetic consequences of escape from East Prussia in affected subjects and their offspring - CELLO

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012419

Enrollment

800

Registered

2017-05-23

Start date

2017-05-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F33 E11

Interventions

Group 1: subjects with early life trauma (East Prussia refugees): using questionnaires, interviews and saliva samples, we will estimate the lifetime risk for diabetes, depression, adiposity and dysreg

Eligibility

Sex/Gender

All

Age

52 Years to 90 Years

Inclusion criteria

Inclusion criteria: own or parental refugee experience

Exclusion criteria

Exclusion criteria: impaired ability to consent

Design outcomes

Primary

Measure	Time frame
life time prevalence of type 2 Diabetes mellitus (questionnaire FindRisk, medication), adiposity (Body mass index), depression (questions of SKID Interview), HPA Dysregulation (diurnal cortisol profile in saliva)	—

Secondary

Measure	Time frame
epigenetic study using Infinium HumanMethylation450 BeadChip in order to test association of specific differential epigenetic modification in subjects with traumatic displacement experience and the above-mentioned phenotypes.	—

Countries

Germany

Contacts

Public ContactMichael Deuschle

Zentralinstitut für Seelische Gesundheit

michael.deuschle@zi-mannheim.de0621 1703 2331

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 9, 2026