B24
Conditions
Interventions
Group 1: Single arm. Interventions: Questionnaires for patients and treating physicians. Collection of 10 mL EDTA blood (during routine checks) for resistance analysis
Sponsors
ICH Study Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Documented HIV-infection, age of at least 18 years, documented triple-class-resistance (NRTIs, NNRTIs, PIs or INSTIs), documented by at least one resistance test), written informed consent
Exclusion criteria
Exclusion criteria: No documented triple-class resistance, medical illness that does not allow safe blood draw, age under 18 years, cognitive impairment leading to inability to fill out the questionnaires and/or to give informed assent or consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concordance between current resistance analysis (evaluated by ultra deep sequencing from proviral DNA) and prior resistance pattern (historical test results) | — |
Secondary
| Measure | Time frame |
|---|---|
| Current antiretroviral therapy, remaining options. Virological and immunological situation. Physical and mental health of the patients. Adherence and treatment satisfaction with current antiretroviral therapy (evaluated by questionnaires) | — |
Countries
Germany
Contacts
Public ContactChristian Hoffmann
Infektionsmedizinisches Centrum Hamburg, ICH Study Center
Outcome results
None listed