K03.2
Conditions
Interventions
Group 1: Analysis of salivary parameter in resting and stimulated saliva in persons with erosion of different origin (Parameter: enzyme activity, proteom, flow rate, buffering capacity)
Group 2: Analy
Sponsors
Stiftungsprofessur für Kariesforschung Klinik für Zahnerhaltungskunde und Parodontologie Department f. Zahn-, Mund- u. KieferheilkundeUniversitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: age of consent; informed written consent; Groups suffering from erosion: BEWE score of at least 2 in at least two sextants
Exclusion criteria
Exclusion criteria: cavitated carious lesions; insufficient fillings reaching the dentine; deep and inflamed periodontal pockets (= 4 mm with bleeding); other serious inflammatory processes in the oral cavity; allergy against the used dental materials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single measurement of the activity of oral proteolytic enzymes (pepsin, trypsin, salivary collagenases, common proteolytic activity) with standard test kits; Single analysis of the saliva proteom; Correlation of the activity and the protein composition with the type of the impacting acid and the occurrence of erosion according to BEWE criteria in the different groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Association of basic salivary parameter, nutrition data, medication and nutrition in the context of an eating disorder with occurence and severity of erosion. | — |
Countries
Germany, Norway
Contacts
Public ContactNadine Schlüter
Stiftungsprofessur für Kariesforschung Klinik für Zahnerhaltungskunde und Parodontologie Department f. Zahn-, Mund- u. KieferheilkundeUniversitätsklinikum Freiburg
Outcome results
None listed