Cardiovascular morbidity
Conditions
Interventions
Group 1: Pupils from classes participating in the mobility program shall be included.
The mobility program consists of a short mobility break within each lesson, as well as a 30 minute long exercise
Sponsors
Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie (HTTG)Medizinische Hochschule Hannover
Eligibility
Sex/Gender
All
Age
6 Years to 19 Years
Inclusion criteria
Inclusion criteria: Second and fifth grade pupils, whose schools participates in the Rebirth active School mobility program.
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Telomere length of DNA from peripheral mononuclear cells (measured by PCR (polymerase chain reaction)) at inclusion, after 1 year and after 2 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| The followig prameters will be analyzed as secondary endpoints at inclusion, after 1year, and after 2 years: Pulse wave velocity will be measured oscillometrically by using the Vicorder device, which is validated for pediatric use. Intima-media thickness will be measured by ultrasound, employing the guidelines of the Mannheim Consensus. p16INK4a-Expression will be determined by RT-PCR in peripheral mononuclear cells. | — |
Countries
Germany
Contacts
Public ContactAnette Melk
Klinik für Pädiatrische Nieren-, Leber- und StoffwechselerkrankungenMedizinische Hochschule Hannover
Outcome results
None listed