Changes of the intercellular interaction between leukocytes and platelets during extracorporeal circulation

Changes of the intercellular interaction between leukocytes and platelets during extracorporeal circulation - 08-AnIt-16

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012349

Enrollment

Registered

2017-04-20

Start date

2017-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.0

Interventions

Group 1: Patients with extracorporeal circulation: Blood withdrawal after induction of general anesthesia (0h), after weaning from CPB (4h) and 24hrs after the end of surgery. Group 2: OPCAB patients

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients CPB and OPCAB: Coronary artery disease with elective myocardial revascularization surgery. Healthy controls: no further criteria.

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Immunosuppressive therapy (within last 7 days) 3. CKD (eGFR < 60 ml/min) 4. known hematologic malignancy 5. HIV infection 6. acute or chronic inflammation 7. medical history of organ transplantion

Design outcomes

Primary

Measure	Time frame
Leukocyte-platelet interactions in flow cytometry at time points 0h, 4h and 24h.	—

Secondary

Measure	Time frame
Release of pro-inflammatory and pro-thrombotic mediators (analyzed by ELISA) at time points 0h, 4h and 24h.	—

Countries

Germany

Contacts

Public ContactJan Rossaint

Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Universitätsklinikum Münster

rossaint@uni-muenster.de0251-8347255

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026