Postoperative time of extubation and incidence of postoperative nausea and vomiting due to intraoperative pupillometry-controlled analgesia

Postoperative time of extubation and incidence of postoperative nausea and vomiting due to intraoperative pupillometry-controlled analgesia - P_AL_EX

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00012329

Enrollment

200

Registered

2017-05-24

Start date

2018-05-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative nausea and vomiting analgesia

Interventions

Group 1: Control group: allocation due to randomisation, Intraoperative opioid administraion (sufentanil) control by clinical parameters (eg heart rate, blood pressure, BIS (bispectraler Index), sweat

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: voluntariness; preoperative written confirmed consent, elective surgery with use of heart-lung machine or implantation of transapical aortic valve (TAVI), adequate knowledge of the German language, 18 years of age

Exclusion criteria

Exclusion criteria: 8.5%, concomitant treatment with opioids or antidepressants, eye drugs for topical application, psychiatric disorder. Secondary: BDI > 20 points, early postoperative complications, intraopertive injection of atropine, MCP/ DHB, intraopertive hypothermia <32°C.

Design outcomes

Primary

Measure	Time frame
• Patients who undergo elective cardiac surgery and receive intraoperative opioids due to pupillometry will be extubated earlier than patients who receive opioids due to clinical parameters (without pupillometry) • Patients with cardiac surgery and intraoperative analgesia due to pupillometry will suffer less postoperative nausea and vomiting than patients who receive opioids due to clinical parameters (without pupillometry)	—

Measure

Time frame

• Patients who undergo elective cardiac surgery and receive intraoperative opioids due to pupillometry will be extubated earlier than patients who receive opioids due to clinical parameters (without pupillometry) • Patients with cardiac surgery and intraoperative analgesia due to pupillometry will suffer less postoperative nausea and vomiting than patients who receive opioids due to clinical parameters (without pupillometry)

—

Secondary

Measure	Time frame
• Postoperative pain (NRS, numerical rating scale, 0-10) on day one and day two after surgery • Incidence of re-Intubation with early respiratory insuffiency (< 24h after extubation). • Intraoperative consumption of analgesics • Postoperative consumption of analgesics on day one and day two after surgery. • Incidence of postoperative delirium on day one and two after surgery. • Intraoperative correlation between pupillometry and BIS. • gender difference for all diagnosed parameter (z.B. PONV, NRS pupil diameter). • Incidence rate on further postoperative complications on day one and two after surgery.	—

Measure

Time frame

• Postoperative pain (NRS, numerical rating scale, 0-10) on day one and day two after surgery • Incidence of re-Intubation with early respiratory insuffiency (< 24h after extubation). • Intraoperative consumption of analgesics • Postoperative consumption of analgesics on day one and day two after surgery. • Incidence of postoperative delirium on day one and two after surgery. • Intraoperative correlation between pupillometry and BIS. • gender difference for all diagnosed parameter (z.B. PONV, NRS pupil diameter). • Incidence rate on further postoperative complications on day one and two after surgery.

—

Countries

Germany

Contacts

Public ContactChristine Meyer-Frießem

Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum

meyer-friessem@ains-bergmannshei.de0049234-3020

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026