Obesity E66
Conditions
Interventions
Group 1: Verum Group: transcutanous vagus nerve stimulation in the cymba conchae of the outer ear using a stimulation device for 4 hours a day throughout a period of 5 weeks with a biphasic frequency
Sponsors
Universitätsklinik zu Lübeck Medizinische Klinik 1 - Klinik für Neurologie
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: male BMI>28kg/m2 healthy normal sleep rhythm 18-45 years fluent in German no transcutaneous Vagus nerve stimulation before last blood samples taken > 4weeks
Exclusion criteria
Exclusion criteria: left handed; vegetarian or vegan diet; Food allergies; smoker/ drug user; on a diet during the trial; sleeping disorders/ shift work; regular drug ingestion; psychological or physiological disease; acute stressful Situation; non-removable magnetic Implants;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight loss after 5 weeks of stimulation measured by weighing. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in fat mass, measured with bioimpedanz Analysis after 5 weeks of stimulation. Improvement of fat and glucose metabolism, measured by blood Parameters like Insulin, Glucose, HbA1c, Cholesterol after 5 weeks of stimulation. Reduction of brain activity in Food-related brain Areas after visual cue stimulation in fMRI after 5 weeks of stimulation. | — |
Countries
Germany
Contacts
Public ContactMartina Obst
Department of neurology
Outcome results
None listed