Pain
Conditions
Interventions
Group 1: After bilateral baseline (BASE) testing twice by the mechanical test stimuli special electrodes were fixed on both ventral forearms to determine the electrical detection threshold. Afterwards
Sponsors
Klinik für Anästhesiologie, Operative Intensivmedizin und Schmerztherapie Universitätsklinikum Münster
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: voluntariness, age 18 - 40 years, regular menstrual cycle varying from 26 to 30 days
Exclusion criteria
Exclusion criteria: pregnancy, lactation, any medication (e. g. hormonal contraceptives, homones, anabolic steroids, analgesic, antidepressants), any pre-existing medical conditions (e.g. diabetes, migraine, multiple sclerosis, psychiatric disorder) or withdrawal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baseline measurement: mechanical pain threshold (with PinPrick; MPT), mechanical pain sensibility (MPS), electrical pain sensibility (EPS), electrical detection threshold (EDT) T0: immediatley after high frequency stimulation (HFS): MPT, MPS, EPS, EDT T1: 1 hour after HFS: MPT, MPS, EPS, EDT T3: three hours after HFS: MPT, MPS, EPS, EDT plus blood sampling T27: 27 hours after HFS: MPT, MPS, EPS, EDT Three measurements: follicular phase, late follicukar phase, luteal phase High levles of progesterone (luteal phase) might amplify an induced primary and/ or secondary hyperalgesia. High levels of estrogen (late follicular phase) might decrease induced hyperalgesia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement for area of hyperalgesia using a brush T0; T1; T3; T27. Regression analysis might detect different gonodal hormones constellations that cause hyperalgesia. | — |
Countries
Germany
Contacts
Public ContactChristine Meyer-Frießem
Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum
Outcome results
None listed