Acid base equilibrium and bone metabolism E87
Conditions
Interventions
Group 1: The study consists out of a 4 week preparatory phase during which the participants will need to supplement vitamin D. This is followed by a 4 week intervention, during which the vitamin D sup
Sponsors
Institut für Lebensmittelwissenschaft und Humanernährung
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: -Healthy, competent men and women aged 18-75 years - omnivorous - BMI 18,5-32 kg/m2 - Ability and willingness of study participamts to follow study leaders instruction - written consent after information about study content, procedure and risks
Exclusion criteria
Exclusion criteria: - allergies regarding study products contents - individuals that follow an alternative diet (e.g. vegetarian, vegan, paleo, food combining) - Intake of medicine that has an influence on calcium- and bone metabolism (diuretics, corticosteroids, anticonvulsants, bisphosphonate) - Intake of calcium or magnesium supplements - diagnosed and treated osteoporosis - Intake of isoflavonoids - hormone replacement therapy 6 months before beginning of the study or during the intervention - severe chronic diseases (diabetes mellitus, kidney disease, liver disease, manifested coronary diseases, cancer, thyroid disease) - individuals with urinary stones or intake of urine acidifying medicine - diagnosed blood coagulation disorder or intake of coagulation-inhibiting medicine - chronic gastrointestinal diseases (colitis ulcerosa, morbus crohn, pancreas insufficiency) - regular intake of laxative medicine - pregnancy or lactation -addiction to alcohol and/or drugs - missing consent or refusal/reset of the consent - participation in another clinical trial at the same time or within the past 30 days - planned surgery within the next 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Net acid excretion (NEA) analitically determined by means of the titratable acid (TA) of the ammonium (NH4+) and bicarbonate (HCO3-) in the urine (NEA = TA + NH4+ – HCO3-) at the beginning and at the end of the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| - parameters of the bone turnover (osteocalcin, carboxy-terminal collagen crosslinks (CTX) in EDTA blood, amino-terminal propeptide of type I collagen (P1NP) at the beginning and and the end of the intervention - potential renal acid load (PRAL) of different mineral waters and the consumed food using valid food questionnaires | — |
Countries
Germany
Contacts
Public ContactPaulina Wasserfurth
Institut für Lebensmittelwissenschaft und Humanernährung
Outcome results
None listed