J80
Conditions
Interventions
Group 1: After getting the informed consent of the patient a decremental peep trial with 6 steps will started to find the lowest driving pressure of this steps. The PEEP level with the lowest driving
Sponsors
Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Leipzig, AöR
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ARDS with followed criteria (all): a. sudden onset b. bilaterale infiltrates in the lung c. PaO2/FIO2 < 300 d. no evidence for a cardial reason of the lung failure 2. intubation and mechanical ventilation
Exclusion criteria
Exclusion criteria: 1. age 7 days of inclusion 3. pregnancy and the breastfeeding 4. severe cardial diseases (New York Heart Association Klassifikation III or IV, acute Ischemia, ventricular rhythm disorders) 5. every neuromuscular disorders 6. patient in an interventional study 3 months before 7. pacemaker or other electrical implantated devices 8. high risk for death within the first 48h 9. DNR order
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of the possibility for a decremental PEEP (positive end-expiratory pressure) titration to detect the lowest PEEP that minimizes ?P | — |
Secondary
| Measure | Time frame |
|---|---|
| Describing the distribution of ventilation in the early stadium of ARDS (Acute respiratory distress syndrome) Effects of an individualized PEEP setting with driving pressure for the distribution of ventilation Determination of endexpiratory lung volume to show the effects after PEEP-titration | — |
Countries
Germany
Contacts
Public ContactPhilipp Simon
Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Leipzig, AöR
Outcome results
None listed