Therapy-induced changes in craniomandibular cerebral representation in CMD patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011931

Enrollment

Registered

2017-03-31

Start date

2017-04-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K07.6

Interventions

Group 1: An individually adapted upper jaw splint of the michigan type is used for 3 weeks. We measure functional magnetic resonance imaging (fMRI) for evaluation cortical representation of emotional

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: cranio-mandibular disorder longer than 6 months more than 4 days a week

Exclusion criteria

Exclusion criteria: depression, teeth loss, radiologic damage of the jaw (degeneration, inflammation, fracture), fibromyalgia, malignoma, heart insufficiency, contraindications for an MRI investigation

Design outcomes

Primary

Measure	Time frame
Changes in movement associated cerebral representation in the fMRI. Activation (anterior insula) associated with changes in pain at rest (VAS) and EMG and Symmetry of the TMJ-movements.	—

Secondary

Measure	Time frame
STAI-values, stress associated Cortisol, fMRI-activation anterior insula and cingulate, occlusal symmetry, EMG-relaxation during rest, connectivity changes in ROIs	—

Countries

Germany

Contacts

Public ContactMartin Lotze

Universitätsmedizin Greifswald

martin.lotze@uni-greifswald.de03834 866899

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026