Metastatic Colorectal Cancer C18
Conditions
Interventions
Group 1: We test if the patients have an all-RAS wild-type or a mutation. On the basis of the pathological molecular biological determination we find out if there exists a K-RAS and N-RAS (All-RAS)-wi
Sponsors
Universitätsklinikum Erlangen
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: ECOG-index: 0-1: Age > 18 years 16 cm from anocutaneous line) or of the rectum with non-resectable distant metastases (synchronous or metachronous) palliative chemonaive patients related to first- line therapy, adjuvant therapy CT/neoadjuvant RT-CT before >= 6 months allowed negative pregnancy test of premenopauseal women Patient signed written consent
Exclusion criteria
Exclusion criteria: - missing patient written consent - e.g. contra-indication against cetuximab, bevacizumab or another therapy Option - age: 75 years - ECOG-index 2: age > 75 years - no initial presentation at an interdisciplinary tumour-board with regard to non-resectability of the distant metastases - no adequate contraception for premenopauseal women - pregnancy and lactation - MSI-tumors (immunohistochemical) - BRAF-V600E-mutation in tumor - Appendix adenocarcinoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| implementation of the interdisciplinary tumour board recommandations | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival; frequency and success of secondary metastatic resection with detection of morbidity and mortality andlLong-term survival time | — |
Countries
Germany
Contacts
Public ContactAxel Wein
Universitätsklinikum Erlangen
Outcome results
None listed