Prospective Analysis of Natriuretic Peptides in Cardiac Surgery for the Prediction of Delirium and Postoperative Neurocognitive Deficits

Prospective Analysis of Natriuretic Peptides in Cardiac Surgery for the Prediction of Delirium and Postoperative Neurocognitive Deficits - ProNaDel

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00011833

Enrollment

Registered

2017-03-03

Start date

2017-03-09

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F05.0

Interventions

Group 1: Patients scheduled for cardiac surgery will be screened for delirium and POCD and biomarkers (i.a. natriuretic peptides) will be determined in patients' blood samples.

Eligibility

Sex/Gender

All

Age

60 Years to 99 Years

Inclusion criteria

Inclusion criteria: sceduled cardiac surgery with cardiopulmonary bypass

Exclusion criteria

Exclusion criteria: combined surgery, emergency surgery, chronic renal disease (GFR < 60 ml/min), liver cirrhosis with hepatic encephalopathy, preexistent psychiatric disease (dementia, schizophrenia, depression), pulmonary arterial hypertension, severe cognitive decline (MMSE < 24), preoperative hemoglobin level < 10g/dl

Design outcomes

Primary

Measure	Time frame
Onset of delirium (Confusion Assessment Method for the Intensive Care Unit, Diagnostic and Statistical Manual of Mental Disorders 5th Edition, Chart-Based-Method within the hospital), POCD (Repeatable Battery for the Assessment of Neuropsychological Status preoperatively, at discharge and 6 months after discharge)	—

Secondary

Measure	Time frame
risi factors, course of surgery and intensive care, sepsis, quality of life (Short Form-36 Health Survey), further parameters	—

Countries

Germany

Contacts

Public ContactThomas Saller

Klinikum der Ludwigs-Maximilians-Universität München, Campus Großhadern

delirstudie@med.uni-muenchen.de089-4400 73410

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026