I48.1
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: ?Documented persistent atrial fibrillation (duration > 4 weeks, < 12 months) ?Planned catheter ablation for symptomatic AF ?First left atrial ablation procedure ?Sinus rhythm prior to the procedure ?Age 18-75 years
Exclusion criteria
Exclusion criteria: ?Contra-indications to catheter ablation therapy ?Patients with paroxysmal ( 55 mm ?LA thrombus ?Previous LA substrate modification/surgery ?Severe structural heart disease, ?Hypertrophic cardiomyopathy ?Mitral prosthesis ?Unstable angina ?Uncontrolled hyperthyroidism ?Stroke or TIA within 6 months ?Myocardial infarction within 2 months ?Cardiac surgery within 3 months ?Thrombocytosis, thrombocytopenia ?Any condition contraindicating chronic anticoagulation ?Pregnancy ?Life expectancy <1year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Feasibility of 3D-multimodal reconstruction representing an atrial map with respect to following parameters: voltage, excitation/conduction, CFAEs, spiral activation patterns in each patient. 2. Junction of the different maps. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Coincidence of the different phenomena and outcome of the procedure. 2. Quantitative AF burden (in % of FU time, 12 weeks of blanking period post ablation). 3. Safety | — |
Countries
Germany
Contacts
Städtisches Klinikum Karlsruhe Medizinische Klinik IV