Multicenter, cross-sectional study investigating the prevalence of defined Clostridium difficile infection (CDI) protective candidate components of the intestinal microbiota

Multicenter, cross-sectional study investigating the prevalence of defined Clostridium difficile infection (CDI) protective candidate components of the intestinal microbiota - CROSSDIFF

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00011801

Enrollment

500

Registered

2018-01-25

Start date

2017-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A04.7

Interventions

Group 1: Patients with CDI: Questionaire, patient questionnaire, stool sample Group 2: Control patients: Questionaire, patient questionnaire, stool sample

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inpatients with indication for the C. difficile diagnostics with positive (cases) or negative (controls) results, informed consent from patients after patient education

Exclusion criteria

Exclusion criteria: CDI or suspected CDI within 30 days prior to enrollment; diseases which prevent candidates to understand the nature and the consequences of the clinical trial; indications for protocol non-compliance

Design outcomes

Primary

Measure	Time frame
Prevalence of potential protective strains of CDI patients vs. controls Identification of components of the commensal microbiota with a protective effect against C. difficile infection	—

Secondary

Measure	Time frame
Compliance with microbiota results from the SPECTRUM-Study	—

Countries

Germany

Contacts

Public ContactOlesya Unruh

MHH OE6810

unruh.olesya@mh-hannover.de+495115323489

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026