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Characterization of performance monitoring in Tourette syndrome and its modulation through deep brain stimulation

Characterization of performance monitoring in Tourette syndrome and its modulation through deep brain stimulation - TOSHI

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00011748
Enrollment
65
Registered
2017-02-09
Start date
2017-07-19
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F95.2

Interventions

Group 1: Patients with Tourette-Syndrom: follow-up after dbs Assesement of: - psychopathological questionnaires (specific for disorder e.g. YGTSS) - neuropsychological tests (TAP with subscales: wor

Sponsors

Uniklinik KölnKlinik für Psychiatrie und Psychotherapie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: • Age 18-60 • Patient approves to be evaluated • Patients have to be capable to give consent • Written informed consent

Exclusion criteria

Exclusion criteria: -clinical relevant psychiatric disorder - severe and instable physical disorder and brain tumors -clinical relevent internal or neurological disorder - pregnancy or breat feeding - suicidal tendencies or violent behavior in the last six months - acute psychotic symptoms - participation in a clinical study prior this study in the last thirty days -withdrawal of informed consent

Design outcomes

Primary

MeasureTime frame
Change of impulsivity will be assesed with a delay discounting paradigma which results in a k-parameter (a high k-paramater indicates high impulsivity and a low k-parameter indicates low impuslvity) and the the baseline k-parameter (assesment before operation) will be compared to the acute effects of the on/off condition. Additionally, a comparison between patients with Tourette's syndrom, DBS-patients with Tourette's syndrom and heathy control subjects will be made.

Secondary

MeasureTime frame
Parameter of effort discounting and task switching. Effects of modulation shall be visualised by comparing the on and off condition. Additionally, a comparison between patients with Tourette's syndrom, DBS-patients with Tourette's syndrom and heathy control subjects will be made.

Countries

Germany

Contacts

Public ContactCanan Peisker

Uniklinik KölnKlinik für Psychiatrie und Psychotherapie

canan.peisker@uk-koeln.de022147898843

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026