Effects of Enovita®, an extract of grape seed, on blood pressure in subjects with mildly elevated blood pressure - a double blind, randomized, placebo-controlled parallel group study

Effects of Enovita®, an extract of grape seed, on blood pressure in subjects with mildly elevated blood pressure - a double blind, randomized, placebo-controlled parallel group study - BTS967/16

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011745

Enrollment

Registered

2017-02-13

Start date

2017-02-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mildly elevated blood pressure (systolic: 125-140 mmHg)

Interventions

Group 1: Enovita® 300 mg/ day (Grape seed Proanthocyanidin) in 2 tablets for 16 weeks Group 2: Placebo (Mikrocristalline Cellulose) 300 mg/ day in 2 tablets for 16 weeks

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Systolic blood pressure between 125 and 140 mmHg without medical treatment BMI between 19 and 32 kg/m2 Non-smoker

Exclusion criteria

Exclusion criteria: Polyphenol high diet ( = 5 portions of vegetables or fruits per day) Intake of blood pressure lowering medication, statins or disturbing supplements

Design outcomes

Primary

Measure	Time frame
reduction of systolic blood pressure (average out of seven days measured at home) after 16 weeks of supplementation	—

Secondary

Measure	Time frame
•Reduction of diastolic blood pressure after 16 weeks of supplementation •7-day blood pressure measurement (systolic/ diastolic) over time: 3 weeks, 7 weeks, 11 weeks and 15 weeks. •24h blood pressure (mean 24 hour and mean day-time systolic/diastolic blood pressure and nocturnal dipping (systolic and diastolic) before and after 16 weeks of supplementation. •Endothelial functionbefore and after 16 weeks of supplementation (lnRHI and AI75)	—

Measure

Time frame

•Reduction of diastolic blood pressure after 16 weeks of supplementation •7-day blood pressure measurement (systolic/ diastolic) over time: 3 weeks, 7 weeks, 11 weeks and 15 weeks. •24h blood pressure (mean 24 hour and mean day-time systolic/diastolic blood pressure and nocturnal dipping (systolic and diastolic) before and after 16 weeks of supplementation. •Endothelial functionbefore and after 16 weeks of supplementation (lnRHI and AI75)

—

Countries

Germany

Contacts

Public ContactClaudia Reule

BioTeSys GmbH

c.reule@biotesys.de+49 (0) 711/31 05 71-47

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026