Skip to content

Role of genetic polymorphisms in drug metabolizing cytochrome P450 enzymes expressed in the brain for affective disorders

Role of genetic polymorphisms in drug metabolizing cytochrome P450 enzymes expressed in the brain for affective disorders - BrainCYP

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00011722
Enrollment
300
Registered
2017-02-15
Start date
2015-05-30
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F31 F32 F33 F34 F38 F39

Interventions

Group 1: Subjects who receive a one-time examination by means of functional magnetic resonance imaging (MRI), including structural and resting perfusion MRI images as well as a blood sampling for gene

Sponsors

Bundesinstitut für Arzneimittel und Medizinprodukte
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: - Written consent to the study - Age restriction: 18-50 years - Healthy to shlightly reduced general condition (ASA 1-2) - BMI over 18 kg/m² - Good german language skills - Willingness and suitability for an MRI examination

Exclusion criteria

Exclusion criteria: - In women: Pregancy or breastfeeding period - Reduced general health condition - Regular drug ingestion (with the exception of Thyroxin (Euthyreose), Statins, ACE-Inhibitiors or oral contraceptives) - Metal implates (for example: pacemaker, copper spiral (in women), claustrophobia) - other contraindications for nuclear resonance imaging - consent incapable - Indication for neurological or psychatric diseases - No appropriate knowledge of german language to work on the questionnaires - not-to-know incidental findings

Design outcomes

Primary

MeasureTime frame
The aim of the present research project is to investigate the role of CYPs in healthy participants to the vulnerability to mental disorders through their action on endogenous substrates in the brain and their resulting effects on brain morphology and function.

Countries

Germany

Contacts

Public ContactJulia Stingl

Bundesinstitut für Arzneimittel und Medizinprodukte

julia.stingl@bfarm.de0228 993073575

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026