Association between perioperative crystalloid infusion management and changes in total body water, extracellular water, hemodynamics, catecholamine dependency, function of Glykokalyx and associated homonal/metabolic signals --- a pilot study

Association between perioperative crystalloid infusion management and changes in total body water, extracellular water, hemodynamics, catecholamine dependency, function of Glykokalyx and associated homonal/metabolic signals --- a pilot study - EPICARD_Pilot

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00011694

Enrollment

Registered

2017-02-08

Start date

2017-03-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.9

Interventions

Group 1: Patients undergoing OPCAB surgery will be monitored regarding perioperative crystalloid fluid administration and catecholamine dependency. Bioimpedance analysis, lung ultrasound and skin fold

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Elective cardiac srugery -- OPCAB only Age > 18 years Written informed consent Patients with or without type-2 diabetes and micro-/ macro-Albuminurea

Exclusion criteria

Exclusion criteria: Study withdrawal Recruitment in other clinical trial Personel of Jena university hospital or relatives Patients undergoing surgery with cardiopulmonary bypass

Design outcomes

Primary

Measure	Time frame
Study Endpoint: To analyze the effect of crystalloid fluid infusion on total body water and composition of the extracellular and intracellular space defined by central and peripheral edema. Catecholamine dependency and renal dysfunction will also be assessed. Measurement: - Bioimpedance Analysis to evaluate body water composition - blood samples to measure Glycocalyx - Lung ultrasound to measure central edema - skin wrinkels to measure peripheral edema - Hemodynamics with Pulse contour cardiac output Timepoint of measurement: - prior anaesthesia - immediately after surgery - on postoperative days 1 and 2 - prior discharge from Intensive care unit - prior hospital discharge	—

Measure

Time frame

Study Endpoint: To analyze the effect of crystalloid fluid infusion on total body water and composition of the extracellular and intracellular space defined by central and peripheral edema. Catecholamine dependency and renal dysfunction will also be assessed. Measurement: - Bioimpedance Analysis to evaluate body water composition - blood samples to measure Glycocalyx - Lung ultrasound to measure central edema - skin wrinkels to measure peripheral edema - Hemodynamics with Pulse contour cardiac output Timepoint of measurement: - prior anaesthesia - immediately after surgery - on postoperative days 1 and 2 - prior discharge from Intensive care unit - prior hospital discharge

—

Secondary

Measure	Time frame
1. Association of total body fluid, hemodynamic and lung water content in the perioperative period 2. Measurement of Gykokalyxdysfunction 3. Expression of hormonactive peptides in the epicardial adipose tissue and blood plasma 4. Metabolomics in epicardial adipose tissue 5. To evaluate differences between patients with type-2 diabetes and patients without diabetes 6 To monitor the clinical outcome	—

Measure

Time frame

1. Association of total body fluid, hemodynamic and lung water content in the perioperative period 2. Measurement of Gykokalyxdysfunction 3. Expression of hormonactive peptides in the epicardial adipose tissue and blood plasma 4. Metabolomics in epicardial adipose tissue 5. To evaluate differences between patients with type-2 diabetes and patients without diabetes 6 To monitor the clinical outcome

—

Countries

Germany

Contacts

Public ContactChristoph Sponholz

Klinik für Anästhesiologie und IntensivmedizinUniversitätsklinikum Jena

christoph.sponholz@med.uni-jena.de03641 – 9 – 32 22 25

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026