Healthy subjects
Conditions
Interventions
Group 1: A healthy control group will receive a neutral tasting placebo drops (aqua dest.), sublingually. Before and after sham treatment a Cold Pressor Test is performed to measure treatment effects.
Sponsors
Universitätsklinikum Essen, Klinik für Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy, informed consent, german language proficiency
Exclusion criteria
Exclusion criteria: •History of, or present neurological disorders (including chronic pain) •History of, or present psychiatric disorders •History of, or present major internal disease. In particualar: any diseases that could interact with the circulatory system effects of the CPT. •Acute infections •Alcohol consumption on the day of, or the day before testing •Surgery within 6 months before testing •Participation in a clinical trial within 6 months before testing •Any long-term medication, except for dietary supplements or contraceptives. •NSAID consumption within 7 days before testing •Pregnancy •Disorders of the skin that may affect pain/cold sensation •Cuts/lesions at the tested extremity •Raynaud's disease •History of recidivate muscle cramps
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area-under-the-curve of pain-ratings obtained in the Cold Pressor Test. The Cold Pressor Test is performed before and after treatment. Main group comparison: interaction of neutral placebo vs bitter placebo with pre vs post treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Area-under-the-curve of pain-ratings over the duration of the Cold-Pressor-Task. Comparisons: placebo groups vs no-treatment group 2. CPT tolerance (time until hand withdrawal) 3. Systolic and diastolic blood pressure changes 4. Heart rate changes 5. Association of main outcome with treatment expectations 6. Association of main outcome with post-hoc ratings of taste | — |
Countries
Germany
Contacts
Public ContactMatthias Zunhammer
Universitätsklinikum Essen, Klinik für Neurologie
Outcome results
None listed