N18.5
Conditions
Interventions
Group 1: Chronic dialysis-dependet patients are treated once with the high-flux dialysis filter used to obtain baseline values. After that 7 treatments with the Theranova dialysis filter will be done.
Sponsors
Universitätsmedizin RostockKlinik für Innere Medizin II
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: at least 1 year dialysis; no dialysis associated incidents; safe vascular access; no acute or chronic infectious diseases; no hospital stay in the past 2 weeks; estimated life expectancy> 6 months; no patients with ongoing immunosuppression in post-natal transplantation; patient's consent
Exclusion criteria
Exclusion criteria: pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main criterion is the characterization of the efficacy of Theranova filters in chronic dialysis patients with regard to the improvement of ABIC and the removal of uremia toxins.The test methods for determining albumin binding capacity (ABIC) were described by Klammt et al. (2008). The ABIC method determines the binding capacity of the Albumin molecule at the binding site II (Gambro-MARS, SPAD (single case albumin dialysis).) The ABIC also correlates inversely with the stage of renal insufficiency in patients with chronic kidney disease, ie, the higher the renal insufficiency the patient has, the worse the ABIC. On days 3, 8 and 22 blood samples are taken before and after the treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is the correlation of further clinical and chemical parameters with the efficacy of the therapy. Are creatinine and urea affected as a surrogate parameter? Is there a positive influence on the protein and phosphate content? | — |
Countries
Germany
Contacts
Public ContactSebastian Koball
Universitätsklinikum RostockZIM 1
Outcome results
None listed