Monitoring cerebral oxygen saturation using near infrared spectroscopy to assess experimentally induced pain: a sequence-randomised, sham-controlled study in volunteers.

Monitoring cerebral oxygen saturation using near infrared spectroscopy to assess experimentally induced pain: a sequence-randomised, sham-controlled study in volunteers. - PAINNIRS.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011575

Enrollment

Registered

2017-02-03

Start date

2013-01-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain healthy controls

Interventions

Group 1: 20 subjects are exposed to four different stimuli within a single session. The first stimulus is always UPS, followed by random assignment to the other three stimuli (cross-over, sequence-con

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1) voluntariness, 2) healthy, 3) right handed, 4) German knowledge, 5) 18-45 years, 6) written infomred consent

Exclusion criteria

Exclusion criteria: 1) missing declaration of consent, 2) left handed, 3) psychiatric disorder, 4) neurological disorder, 5) disorders like diabetes, polyneuropathy, 6) exposure to medications for analgesia/ hormones, antidepressants, 7) chronic pain

Design outcomes

Primary

Measure	Time frame
Decrease of cererbal oxygen saturation atfer pain stimulus (each stimulus (UPS, EPS, NPS or PS) was set at ‘0s’, pre-base 1: prior to UPS at ‘-300 to 0s’, pre-base 2 prior EPS, NPS or PS at ‘-180 to -30s’. Warning was given verbally 30s before the stimuli (‘-30 to 0s’). After each stimulus the observational period was divided into different time intervals of about 30s. Post-base ‘150 to 300s’.	—

Measure

Time frame

Decrease of cererbal oxygen saturation atfer pain stimulus (each stimulus (UPS, EPS, NPS or PS) was set at ‘0s’, pre-base 1: prior to UPS at ‘-300 to 0s’, pre-base 2 prior EPS, NPS or PS at ‘-180 to -30s’. Warning was given verbally 30s before the stimuli (‘-30 to 0s’). After each stimulus the observational period was divided into different time intervals of about 30s. Post-base ‘150 to 300s’.

—

Secondary

Measure	Time frame
pain intensity on NRS (numerical rating scale; 0 = no pain, 10 = most intense pain imaginable) after expected and an unexpected painful electrical stimuli	—

Countries

Germany

Contacts

Public ContactChristine Meyer-Frießem

Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum

meyer-friessem@ains-bergmannshei.de0049234-3020

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026