Changes in metabolome and epigenome after drastic weight loss and identification of novel forms of monogenetic obesity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00011537

Enrollment

200

Registered

2017-01-20

Start date

2018-01-08

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extreme Obesity Genetic disposition E66

Interventions

Group 1: Due to live style modification in context of a long-term obesity therapy adolescent will undergo great weight loss. We want to compare metabolic and epigenetic changes before and after weight

Eligibility

Sex/Gender

All

Age

10 Years to 30 Years

Inclusion criteria

Inclusion criteria: Extreme Obesity

Exclusion criteria

Exclusion criteria: Subject do not want genetic analysis. Obesity is caused by underlying disease e.g. Brain tumor, Prader-Willi syndrome…

Design outcomes

Primary

Measure	Time frame
Changes in the metabolome and epigenome during lifestyle interventions. Therefore, we evaluate blood samples taken on the first and last day of long-term weight loss therapy. Blood samples are taken routinely before and after therapy.	—

Secondary

Measure	Time frame
Comparison between “good weight reducer” vs. “low weight reducer” on the basis of weight development and metabolic/epigenetic parameters. Exclusion of underlying monogenetic causes of obesity by observation of weight development and metabolic parameter.	—

Countries

Germany

Contacts

Public ContactPauline Kleger

Sektion Pädiatrische Endokrinologie und Diabetologie Interdisziplinäre Adipositasambulanz Universitätsklinik für Kinder- und Jugendmedizin UlmUniversitätsklinikum Ulm

pauline.kleger@uniklinik-ulm.de0731/50057406

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026