Validation of transcranial Dopplersonography as a monitoring technique of the cerebral circulation during general anaesthesia.

Validation of transcranial Dopplersonography as a monitoring technique of the cerebral circulation during general anaesthesia. - no

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011535

Enrollment

Registered

2017-02-07

Start date

1991-02-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral blood flow and blood flow velocity during general anesthesia

Interventions

Group 1: Effect of argon gas inhalation. (Quality control, internal validity analysis). Crossover measurements: all 30 patients. a) Baseline measurements including parameters of transcranial Doppler-

Eligibility

Sex/Gender

Male

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: - scheduled for elective coronary surgery.

Exclusion criteria

Exclusion criteria: - older than 80 yr of age; - female sex; - active neurological disease; - history of cerebrovascular disease; - brain injury; - intracranial surgery; - Instable angina pectoris (emergency procedure); - Severe aortic valve stenosis; - Liver failure - patient refusal,

Design outcomes

Primary

Measure	Time frame
The study has been planned and conducted before CONSORT Statement (Consolidated Standards of Reporting Trials). The purpose of this trial is to compare measurements of blood flow velocity in the middle cerebral artery (Vmca) by transcranial Doppler sonography (TCD) with measurements of global cerebral blood flow (CBF) by modified Kety-Schmidt-Technique (KST) using argon gas as indicator. Main outcome measures: Changes in mean blood flow velocity of the middle cerebral artery (Vmca) and cerebral blood flow (CBF), cerebral blood flow reactivity (CO2-R), cerebral delivery of oxygen (cDO2), cerebral rate of oxygen, glucose and lactate efflux (CMRO2, CMRG, CMRL), cerebrovascular resistance (CVR), cerebral perfusion pressure (CPP), and TCD- derived parameters of flow (FI), resistance (RI) and pulsatility (PI).	—

Measure

Time frame

The study has been planned and conducted before CONSORT Statement (Consolidated Standards of Reporting Trials). The purpose of this trial is to compare measurements of blood flow velocity in the middle cerebral artery (Vmca) by transcranial Doppler sonography (TCD) with measurements of global cerebral blood flow (CBF) by modified Kety-Schmidt-Technique (KST) using argon gas as indicator. Main outcome measures: Changes in mean blood flow velocity of the middle cerebral artery (Vmca) and cerebral blood flow (CBF), cerebral blood flow reactivity (CO2-R), cerebral delivery of oxygen (cDO2), cerebral rate of oxygen, glucose and lactate efflux (CMRO2, CMRG, CMRL), cerebrovascular resistance (CVR), cerebral perfusion pressure (CPP), and TCD- derived parameters of flow (FI), resistance (RI) and pulsatility (PI).

—

Secondary

Measure	Time frame
(A) Parameters of the systemic und pulmonal circulation Blood gas analysis. (B) Secondary analysis: cerebraler Zero Flow Pressure (ZFP), effektiver cerebral perfusion pressure (CPPe), Resistance area product (RAP).	—

Countries

Germany

Contacts

Public ContactStephan Kazmaier

Universitätsmedizin Göttingen Georg-August-Universität Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin (ZARI)

kazmaier@med.uni-goettingen.de+49 (0)551 39 22995

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026