K02.1 K02.9
Conditions
Interventions
Group 1: Application of Clearfil Protect Bond (Kuraray), a self-etching adhesive, which is known to have antibacterial effect beneath ist adhesive function which is dued to its ingredient, the antibac
Sponsors
Universitätsklinikum Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: •primary caries lesions at 2 (or more) molars or premolars with indication for a stepwise or partial caries removal (regardless of the present trial). Two of the lesions will be included into the study. -clinical picture: ICDAS 4, 5 or 6 -extension in the X-ray picture: R4 (inner half of the dentin) -no pulpal symptoms of the teeth to be included into the study -maintained sensibility of the study teeth •informed consent
Exclusion criteria
Exclusion criteria: • known history of intolerance towards one of the adhesive systems or one of their ingredients • unability of determining study outcome and probable consequences (e.g. because of alcoholism) • refusal to give consent • pregnancy, breastfeeding • inadequate adherence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the antibacterial effect of Clearfil Protect Bond on residual caries compared to Clearfil SE Bond 2. Sampling of carious material at the first visit and at a reentry after eight weeks. Samples are analyzed by microbiological and molecular biological methods (as described in the summary). Changes in microbiological composition are determined quantitatively (qPCR) as well as qualitatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination of the bacterial composition of progressed dentin caries lesions before and after partial caries removal and application of different therapy strategies | — |
Countries
Germany
Contacts
Public ContactJana Schmidt
Poliklinik für Zahnerhaltung und Parodontologie
Outcome results
None listed