Sedation of ventilated patients
Conditions
Interventions
Group 1: Inhalation sedation with Desflurane administered by the reflection system Mirus(TM)
Group 2: Inhalation sedation with Isoflurane, administered by the reflection system Mirus(TM)
Sponsors
Universitätsklinikum des Saarlandes
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age >= 18 years and expected time of invasive ventilation and sedation >24 hours
Exclusion criteria
Exclusion criteria: sedation > 48 hours before start of study medication. contra indications for administration of volatile anaesthetics (pregnancy, malignant hyperthermia) tidal volume < 300 ml (< 200 ml if ECMO is used) severe acute neurological illness, head injury with significant intracranial bleeding, high probability of diffuse axonal injury because of trauma mechanism or other accompagning injuries, poor prognosis (expected survival time < 24 hours), inability to follow simple verbal commands (before ICU stay) history of deafness, history of malignant hyperthermia of the patient or her/his Family.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 80% decrement time (time until the concentration of the volatile anaesthetic in the expired air has decreased to 20% of baseline); time to first eye opening, time to first Hand grip on command, time to first movement of a specified extremity on command, time to Narcotrend Stadium A (electroencephalographic anaesthesia Monitor) percentage of time when the Patient was breathing spontaneously. | — |
Primary
| Measure | Time frame |
|---|---|
| Context sensitive half time, i.e. time until the concentration of the volatile anaesthetic in the expired air has decreased to 50% of baseline, measured in a sedation window (awakening test). | — |
Countries
Germany
Contacts
Public ContactAndreas Meiser
Klinik für Anästhesiologie, Intensivmedizin und SchmerztherapieGeb. 57Universitätsklinikum des Saarlandes
Outcome results
None listed