Autoimmune Lymphoproliferative Syndrome
Conditions
Interventions
Group 1: observation of patients with chronic benign lymphoproliferation and Autoimmune disease
Sponsors
Universitätsklinikum FreiburgCentrum für Chronische Immundefizienz (CCI)
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Chronic benign lymphoproliferation (i.e. splenomegaly +/- lymphadenopathy at 2 sites without infectious or malignant cause) AND 2.Autoimmune disease (i.e. AI cytopenia OR inflammatory bowel disease OR CNS inflammatory disease OR interstitial lung disease) OR one of the two above manifestions AND 3.At least one factor indicating a primary immunodeficiency (i.e. infection susceptibility OR additional autoimmune or inflammatory manifestations OR hypogammaglobulinemia OR aberrant immunophenotype OR positive family history OR consanguinity)
Exclusion criteria
Exclusion criteria: No written informed consent of patient or parents (in case of minors) has been obtained
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Use the clinical, immunological and genetic data in this cohort to establish a diagnostic algorithm for patients with AL-PID | — |
Countries
Germany
Contacts
Public ContactStephan Ehl
Universitätsklinikum FreiburgCentrum für Chronische Immundefizienz (CCI)
Outcome results
None listed