Improvement of a severe hand function disorder after stroke by a facilitating 1mA tDCS over the ispiläsionale primary motor cortex.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011315

Enrollment

158

Registered

2016-11-11

Start date

2017-12-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand function disorder after stroke G81.9

Interventions

Group 1: Patients who have a severe hand function disorder will have a 1mA DC (direct current) stimulation (20 minutes) over the ipsiläsional primary motor cortex in combination with a simultaneous, 6

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: first stroke severe hand function disorder

Exclusion criteria

Exclusion criteria: 1. Demential impairment defined by the Minimental Status Examination = 24 (Folstein et al., 1975), 2. Depression defined by the Beck's Depression Inventory <18 (Beck et al., 1996)), 3. Aphasia, apraxia, neglect, or visual impairment 4. Coexisting psychiatric or neurological disorders 5. Consuming diseases or impaired bodily or mental fitness 6. Non-executable persons and persons in official or judicial custody. 7. Contraindications for transcranial magnetic stimulation (electromagnetic body implants, such as any metal implanted in the head (except the mouth), cochlear implants, implanted brain stimulators, ocular implants, aneurysm clips or stents, cardiac pacemakers, cardioverter defibrillators, implanted medication pumps or intracardiac lines, significant heart disease, cerebrovascular disease, hearing loss, history of epilepsy, dementia, head trauma, increased intracranial pressure, or central nervous system (CNS) tumors).

Design outcomes

Primary

Measure	Time frame
The motor function of the affected hand is examined by means of two hand function tests ( "Wolf Motor Hand Function Test", "Motor Evaluation Scale for Upper Extremity in Stroke Patients"). The investigations are carried out in each case immediately before and after the 2-week intervention.	—

Secondary

Measure	Time frame
The cortical hand representation will be probed by transcranial magnetic stimulation with a stimulation intensity of 110% of the resting motor threshold The stimulation coil is shifted over the skull overlying the primary motor cortex in steps of one centimeter. In each position 5 pulses are applied. The position is defined as "active" when an identifiable MEP (=50 µV) can be triggered in a relaxed contralateral hand muscle with at least 2 (of 5) passages. From this data, the size, the extent and the position of the cortical hand representation are calculated. The motor resting treshold is re-determined for each patient at each test time. It is defined as the lowest stimulator output intensity that can trigger an identifiable motor response potential (MEP) of =50 µV (at a stimulation of the optimal stimulus location) in a relaxed contralateral hand muscle, at least 50% of the passages. For testing the cortical excitability, a commercially available magnetic stimulator with a butterfly coil is used (Magstim Company, Dyfed, UK). The electromyographic activity is measured by two electrodes (belly tendon montage). The coil is positioned over the motor representation of the first interosseous dorsal muscle with an orientation of 45 ° to the sagittal. Two tests of cortical excitability are performed: a test of the motor rest and a test of the cortical hand representation. The measurements are made before and after the one-time intervention.	—

Measure

Time frame

The cortical hand representation will be probed by transcranial magnetic stimulation with a stimulation intensity of 110% of the resting motor threshold The stimulation coil is shifted over the skull overlying the primary motor cortex in steps of one centimeter. In each position 5 pulses are applied. The position is defined as "active" when an identifiable MEP (=50 µV) can be triggered in a relaxed contralateral hand muscle with at least 2 (of 5) passages. From this data, the size, the extent and the position of the cortical hand representation are calculated. The motor resting treshold is re-determined for each patient at each test time. It is defined as the lowest stimulator output intensity that can trigger an identifiable motor response potential (MEP) of =50 µV (at a stimulation of the optimal stimulus location) in a relaxed contralateral hand muscle, at least 50% of the passages. For testing the cortical excitability, a commercially available magnetic stimulator with a butterfly coil is used (Magstim Company, Dyfed, UK). The electromyographic activity is measured by two electrodes (belly tendon montage). The coil is positioned over the motor representation of the first interosseous dorsal muscle with an orientation of 45 ° to the sagittal. Two tests of cortical excitability are performed: a test of the motor rest and a test of the cortical hand representation. The measurements are made before and after the one-time intervention.

—

Countries

Germany

Contacts

Public ContactKathrin Bösl

VAMED Klinik Kipfenberg

kathrin.boesl@vamed-gesundheit.de00498465175183

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026