F10.2
Conditions
Interventions
Group 1: Arm 1 - 50 alcoholics receive at the beginning of withdrawal phase calcium (800 mg) + vitamin D (5 µg) as diatry supplements.
Group 2: Arm 2 - 50 alcoholics receive at the beginning of withd
Sponsors
Zentralinstitut für Seelische GesundheitKlinik für Abhängiges Verhalten und Suchtmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria are male and female alcohol-addicts, age: 18-70 years with diagnosis of alcohol dependence according to ICD-10 criteria. Because of frequently existing comorbid depressive symptoms, an existing depressive medication is limited to the drugs Sertralin (Zoloft®) und Remergil (Mirtazapin®). The ability to agreement after Fully Informed Consent and existing Written Informed Consent) is presupposed.
Exclusion criteria
Exclusion criteria: - alcohol-addicts younger 18 years or older than 70 years - dependence of other substances (nicotine allowed) - drug treatment, which influences the results of the study, especially patients with intake of thiazide, tetracycline, sodium fluoride, bisphosphonates and corticosteroids - fatal physical sickness, especially of the calcium metabolism, operation of thyroid gland or parathyroid and kidney or adrenal sickness - fatal hypertonia or increased cardiovascular risk profile - female: pregnancy (with pregnancy test) - intake of anti-craving drugs - anti-craving drugs shoud be settled out prior two weeks - suicidal tendency or degree of competition from outside suppliers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is it possible to reduce craving and relapse to anew alcohol consumption via a calcium diatry supplement in alcohol-addicts? The primary goal is the relapse and the second goal is craving. Patients are asked to write down their daily volume intake via a drink protocol. Moreover the have to documentate alcohol consumption (relapse) and beverage type. With or without relapse to a alcohol consumption, the survey duration is 2 month. In these 2 month there are 5 measure days (day 1, 7, 14, 28, 60). Craving is measured via the OCDS (Obsessive-Compulsive Drinking Scale) and VAS (visual analog scale). | — |
Secondary
| Measure | Time frame |
|---|---|
| Is there an association between volume-regulating peptides (ANP and vasopressin) and calcium balance? Via blood withdrawal at 5 differnt time points, volume-regulating peptides (ANP and vasopressin) will be measured. | — |
Countries
Germany
Contacts
Public ContactRilana Schuster
Zentralinstitut für Seelische Gesundheit MannheimKlinik für Abhängiges Verhalten und Suchtmedizin
Outcome results
None listed