Effects of mild hyper- and hypothyroidism
Conditions
Interventions
Group 1: Induction of mild biochemical hyper- or hypothyroidism by application of thyroxine to healthy volunteers or by reduction of the thyroxine dose in patients depending on a full thyroxine substi
Sponsors
Klinik für NeurologieUKSH Campus Lübeck
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Hyperthyroidism: healthy volunteers Hypothyroidism: patients under thyroxine substitution
Exclusion criteria
Exclusion criteria: any severe general disease, no cardovascular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive functions were assessed by resting state and functional MRI under short-term memory challenge. Arterial spin labelling, voxel based morphometry as well as a battery of neuropsychological tests (visual analogue scale for hyper- or hypothyroidism, battery for attention testing, attention network task, trail making task, auditory verbal learning test both during euthyroidism and following 8 weeks of alteration of thyroid function as tested by thyroid function tests in the 2 groups of test subjects will be used. | — |
Secondary
| Measure | Time frame |
|---|---|
| New biomarkers derived from serum and plasma samples in parallel to the samples obtained for thyroid function tests will be used. During the alteration of thyroid function but also in the recovery period up to 8 weeks after we will use an unsupervised approach by the help of proteomics and metabolomics techniques. | — |
Countries
Germany
Contacts
Public ContactThomas Münte
Klinik für NeurologieUKSH Campus Luebeck
Outcome results
None listed