Influence of metamizole (dipyrone) on the volume balance during intensive care after cardiac surgery

Influence of metamizole (dipyrone) on the volume balance during intensive care after cardiac surgery - METVOL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00011241

Enrollment

Registered

2016-10-25

Start date

2016-12-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative volume balance during intensive care

Interventions

Group 1: Postoperative pain is treated routinely using a dipyrone infusion and optionally additional bolus doses of other analgesics. Selection, duration of application, and dosage of analgesics follo

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Elective isolated coronary artery bypass grafting using a sternotomy; ability to provide written informed consent

Exclusion criteria

Exclusion criteria: instable circulation (use of catecholamines); preoperative chronic pain medication

Design outcomes

Primary

Measure	Time frame
Significant influence of dipyrone dosage on volume balance within the first 24 h post-op. Volume balance is calculated as the difference of routinely collected data about volume uptake (e.g. infusions, blood products) and volume excretion (e.g. urine, drainages, gastric juice, hemodialysis)	—

Secondary

Measure	Time frame
Volume balance at the end of ICU stay; cumulative vasopressor dosage within the first 24 h post-op; cumulative vasopressor dosage until end of ICU stay; duration of vasopressor treatment; number of packaged red blood cell units used during intensive care; cumulative dosage of analgesics during intensive care; hemodynamic parameters (pulse frequency, central venous blood pressure via central venous catheter, arterial blood pressure via arterial line or Riva-Rocci); pain score (self-assessment of the patient using a numeric scale, or a symbolic faces scale if the patient is illiterate or has restricted communication abilities; measured every 60 min if the patient is sufficiently alert).	—

Measure

Time frame

Volume balance at the end of ICU stay; cumulative vasopressor dosage within the first 24 h post-op; cumulative vasopressor dosage until end of ICU stay; duration of vasopressor treatment; number of packaged red blood cell units used during intensive care; cumulative dosage of analgesics during intensive care; hemodynamic parameters (pulse frequency, central venous blood pressure via central venous catheter, arterial blood pressure via arterial line or Riva-Rocci); pain score (self-assessment of the patient using a numeric scale, or a symbolic faces scale if the patient is illiterate or has restricted communication abilities; measured every 60 min if the patient is sufficiently alert).

—

Countries

Germany

Contacts

Public ContactKarl Träger

Universitätsklinikum Ulm, Kardioanästhesiologie

karl.traeger@uniklinik-ulm.de++49-731-500-55425

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026