The influence of the sleep-wake cycle on the immune response after yellow fever vaccination

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011239

Enrollment

Registered

2016-10-26

Start date

2016-10-27

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Yellow fewer vaccination

Interventions

Group 1: Vaccination against yellow fever (Stamaril - YF17D 20) in the morning (8:00 h), placebo injection in the evening (20:00 h) Group 2: Placebo injection in the morning (8:00 h), vaccination agai

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: - Body mass index between 20-25 kg/m2

Exclusion criteria

Exclusion criteria: Acute or chronic diseases, shift or night work in the last 6 weeks, sleep disorders, smoking, drug intake (except contraceptives), known allergy against components of the vaccine, pregnancy/breastfeeding.

Design outcomes

Primary

Measure	Time frame
- Acute inflammatory response in the first two nights after vaccination. We will measure cytokines, CRP, liver enzymes, fibrinogen, differential blood count and hormones in blood via standard laboratory assays. Measurements take place at 22:00, 2:00 and 6:00 h in the 2 nights after vaccination - Yellow fever specific T and B cell response (measured via FACS and by antibody titres in serum), viremia in the weeks 1, 2, 4, 12 and 52 after vaccination - Influence of the vaccination on sleep (measured by polysomnography) in the first two nights after vaccination	—

Measure

Time frame

- Acute inflammatory response in the first two nights after vaccination. We will measure cytokines, CRP, liver enzymes, fibrinogen, differential blood count and hormones in blood via standard laboratory assays. Measurements take place at 22:00, 2:00 and 6:00 h in the 2 nights after vaccination - Yellow fever specific T and B cell response (measured via FACS and by antibody titres in serum), viremia in the weeks 1, 2, 4, 12 and 52 after vaccination - Influence of the vaccination on sleep (measured by polysomnography) in the first two nights after vaccination

—

Secondary

Measure	Time frame
- Influence of the vaccination on declarative memory (classical game "pairs" as computer version; lerning takes place at 22:00 h in the evening after vaccination; memory recall takes place at 22:00 h one day later). - Influence of the vaccination on mood (mesured by the questionnaires MDBF and PANAS), sickness behavior (measured with the questionnaire SicknessQ) and fatigue (measured by the BFI questionnaire). The questionnaires are giben at 22:00 in the evening after vaccination as well as at 7:00 and 22:00 h on the two first days after vaccination and 1, 2, 4, 12 and 52 weeks later.	—

Measure

Time frame

- Influence of the vaccination on declarative memory (classical game "pairs" as computer version; lerning takes place at 22:00 h in the evening after vaccination; memory recall takes place at 22:00 h one day later). - Influence of the vaccination on mood (mesured by the questionnaires MDBF and PANAS), sickness behavior (measured with the questionnaire SicknessQ) and fatigue (measured by the BFI questionnaire). The questionnaires are giben at 22:00 in the evening after vaccination as well as at 7:00 and 22:00 h on the two first days after vaccination and 1, 2, 4, 12 and 52 weeks later.

—

Countries

Germany

Contacts

Public ContactLuciana Besedovsky

Institut für Medizinische Psychologie und Verhaltensneurobiologie

luciana.besedovsky@uni-tuebingen.de070712988923

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026