Effects of urban versus rural upbringing on the physiological and immunological changes during/following acute social stress in humans.

Effects of urban versus rural upbringing on the physiological and immunological changes during/following acute social stress in humans. - URSS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00011236

Enrollment

Registered

2016-10-24

Start date

2016-10-29

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy population

Interventions

Group 1: subjects, who grew up in the counrtyside: Assessment of pro-inflammatory and anti-inflammatory responses, both under basal conditions and following acute psychosocial stressor exposure, induc

Eligibility

Sex/Gender

Male

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: BMI between 20 and 30; raised (until the age of 15) either in a rural (n=20) or urban (n=20) environment

Exclusion criteria

Exclusion criteria: smoking; current infections; chronic affective or somatic disorders; more than 4 hours of exercise per week; acute exercise within 24 h before blood draws; drug taking (NSAID, cannabis, etc.); acutely (within the last 6 months) bereaved or divorced

Design outcomes

Primary

Measure	Time frame
in vitro cytokine production by peripheral blood mononuclear cells (PBMCs) during concanavalin A or lipopolysaccheride (LPS) stimulation	—

Secondary

Measure	Time frame
plasma cytokine- and stress hormone concentrations	—

Countries

Germany

Contacts

Public ContactSascha Hackl

Universitätsklinikum Ulm, Klinik für Psychosomatische Medizin und Psychotherapie

sascha.hackl@uni-ulm.de0731/500-61940

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 6, 2026