Respiratory mechanics and ventilation using controlled exspiration (FLEX) in obese patients having elective surgery under general anesthesia

Respiratory mechanics and ventilation using controlled exspiration (FLEX) in obese patients having elective surgery under general anesthesia - FLEX Adip

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011182

Enrollment

Registered

2016-10-11

Start date

2016-12-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative mechanical ventilation

Interventions

Group 1: Application of positive end-exspiratory pressure (PEEP) of 7mbar for 5 minutes of calibration followed by 20 minutes for data collection. Then Cross-over with PEEP of 7mbar in addition to con

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: elective surgery, controlled ventilation, Obesity (BMI>30kg/m2)

Exclusion criteria

Exclusion criteria: known lung diseases, Pacemaker, implantable cardioverter/defibrillator, intracardial malformation

Design outcomes

Primary

Measure	Time frame
non-linear intratidal Compliance calculated with the generated respiratory data using the gliding-SLICE method. Respiratory data are collected during the entire experiment, calculation of compliance is performed after terminating the experiment. (see also: Schumann et al. Estimating intratidal nonlinearity of respiratory system mechanics: a model study using the enhanced gliding-SLICE Method Physiol Meas 2009 Dec; 30:1341-1356; Schumann et al. Analysis of dynamic intratidal compliance in a lung collapse model. Anesthesiology 2011 May;114(5):1111-1117)	—

Measure

Time frame

non-linear intratidal Compliance calculated with the generated respiratory data using the gliding-SLICE method. Respiratory data are collected during the entire experiment, calculation of compliance is performed after terminating the experiment. (see also: Schumann et al. Estimating intratidal nonlinearity of respiratory system mechanics: a model study using the enhanced gliding-SLICE Method Physiol Meas 2009 Dec; 30:1341-1356; Schumann et al. Analysis of dynamic intratidal compliance in a lung collapse model. Anesthesiology 2011 May;114(5):1111-1117)

—

Secondary

Measure	Time frame
Oxygenation (SaO2, PaO2) determined by arterial blood gas samples; point in time: after calibration (t0),after 10 minutes (t1) and after 20 minutes (t2)	—

Countries

Germany

Contacts

Public ContactSteffen Wirth

Klinik für Anästhesiologie und Intensivmedizin

steffen.wirth @uniklinik-freiburg.de0761 270 23050

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026