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Multicenter, randomized, controlled trial of remote ischemic preconditioning in the surgical management of gliomas

Multicenter, randomized, controlled trial of remote ischemic preconditioning in the surgical management of gliomas - RIP_G

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00011175
Enrollment
440
Registered
2016-10-11
Start date
2017-07-20
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glioma, brain tumor C71.9 I63.9

Interventions

Group 1: A blood pressure cuff is attached to the arm (contralateral to the brain tumor) and inflated three times for 5 minutes at 200 mmHg in the treatment group after induction of anesthesia. Betwee

Sponsors

Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with suspected primary brain tumor for which surgical resection is planned; Consent to participate in the study; Age> 18.

Exclusion criteria

Exclusion criteria: Non OP-enabled patient (from anesthesiological, medical or surgical view); Patients who have to be operated immediately without extensive preoperative diagnosis; Lack of surgical consent; Lack of consent to participate in the study; Pregnancy; Age <18 years; History of peripheral arterial disease (PAD) or DM with use of oral antidiabetics.

Design outcomes

Primary

MeasureTime frame
Volume of ischemia assessed by direct postoperative cMRI (<72h)

Secondary

MeasureTime frame
neurological deficits (NIHSS one week postoperative/discharge), clinical status (KPS one week postoperative/discharge), time to tumor progression, overallsurvival, hemodynamic parameters during surgery

Countries

Austria, Germany

Contacts

Public ContactJens Gempt

Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar

jens.gempt@tum.de08941409722

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026