Clinical effect of three additional methods (two antimicrobial photodynamic therapy systems and chlorhexidine) to non-surgical treatment of peri-implantitis: a randomized prospective study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011171

Enrollment

Registered

2017-03-13

Start date

2012-03-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implantitis

Interventions

Group 1: Debridment, photodynamic therapy, Helbo Laser Group 2: Debridment, photodynamic therapy, Handy sprint Laser Group 3: Debridement, Irrigation with chlorhexidin

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria have been a peri-implantitis, which were not treated before with probing depth (PD) > 5 mm, bleeding on probing (BoP) and bone loss in the x-ray

Exclusion criteria

Exclusion criteria: Exclusion criteria have been to maintain therapy or to receive peri-implant treatment during the last six months; using antimicrobials (systemic or topical), anti-inflammatory or immunosuppressive drugs during the three months preceding the study

Design outcomes

Primary

Measure	Time frame
Clinical (bleeding on probing (BoP), pus, modified plaque index, pocket depth (PD), and crevicular fluid) mikrobiological parameters after three month. measurement of bleeding on probing at 6 probing points with a periodontal probe. Pus registration out of the sulcus was measured clinical. The modified plaque indes of Sillnes and Loe was used. To measure the pocket probing depth a periodontal probe was used. The sulks fluid was measured using blotting paper. The concentration of alpha MMP-8 was examined using a kitten (diagnostika) and the periodontal pathogens have been identified from the company (Hain Life science, MicroIdentPlus).	—

Measure

Time frame

Clinical (bleeding on probing (BoP), pus, modified plaque index, pocket depth (PD), and crevicular fluid) mikrobiological parameters after three month. measurement of bleeding on probing at 6 probing points with a periodontal probe. Pus registration out of the sulcus was measured clinical. The modified plaque indes of Sillnes and Loe was used. To measure the pocket probing depth a periodontal probe was used. The sulks fluid was measured using blotting paper. The concentration of alpha MMP-8 was examined using a kitten (diagnostika) and the periodontal pathogens have been identified from the company (Hain Life science, MicroIdentPlus).

—

Secondary

Measure	Time frame
clinical and microbiological parameter from E1-E5	—

Countries

Germany

Contacts

Public ContactJulia Karbach

Klinik für Mund-, Kiefer- und Gesichtschirurgie, Plastische Operationen, Universitätsmedizin Mainz,

jkarbach@uni-mainz.de06313-174159

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026