Effects of the Buchinger Wilhelmi fasting program on energy metabolism and muscle function in humans

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00011165

Enrollment

Registered

2016-10-24

Start date

2016-10-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fasting in healthy subjects

Interventions

Group 1: 10 days fast under the conditions of the Buchinger Wilhelmi fasting program

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: - healthy persons - BMI between 20 - 32 kg/m² - signed declaration of consent

Exclusion criteria

Exclusion criteria: - chronic physical disease or psychiatric disorder - Smoking - participation in another study - pregnancy or breastfeeding period - intake of antibiotics up to 2 months before study begin - intake of pre-/pro- and synbiotics up to 4 weeks before the study

Design outcomes

Primary

Measure	Time frame
- physical properties of muscle function (daily measurement of tone, biomechanical properties, elasticity, relaxation, creep and grip strength by Myoton)	—

Secondary

Measure	Time frame
1) regional and whole body composition (bioelectrical impedance analysis: fat mass, lean mass, body water) before, in the middle, at the end and up to 3 months after fasting 2) resting metabolic rate (indirect calorimetry) and sympathetic nervous system activity (24 h - ECG) before, in the middle, at the end and after fasting 3) stress, hunger, mood and their hormonal regulations (VAS, questionnaires, blood Analysis: Insuline, Adiponectine, Leptine, Irisine, acylated Ghrelin, GLP-1, PYY, CKK; Urine: cortisol, normetanephrine, metanephrine, total N, Urea, 3-methyl-histidine are measured before, during, at the end and up to 3 months after fasting 4) inflammatory and oxidative stress markers (blood Analysis) are measured before, during, at the end and up to 3 months after fasting 5) intestinal microbiota and marker of the intestinal permeability before, during and up to 3 months after fasting 6) physical activity before, during and after fasting (accelerometry) 7) breath test before, during and after fasting to evaluate fatty acid oxidation	—

Measure

Time frame

1) regional and whole body composition (bioelectrical impedance analysis: fat mass, lean mass, body water) before, in the middle, at the end and up to 3 months after fasting 2) resting metabolic rate (indirect calorimetry) and sympathetic nervous system activity (24 h - ECG) before, in the middle, at the end and after fasting 3) stress, hunger, mood and their hormonal regulations (VAS, questionnaires, blood Analysis: Insuline, Adiponectine, Leptine, Irisine, acylated Ghrelin, GLP-1, PYY, CKK; Urine: cortisol, normetanephrine, metanephrine, total N, Urea, 3-methyl-histidine are measured before, during, at the end and up to 3 months after fasting 4) inflammatory and oxidative stress markers (blood Analysis) are measured before, during, at the end and up to 3 months after fasting 5) intestinal microbiota and marker of the intestinal permeability before, during and up to 3 months after fasting 6) physical activity before, during and after fasting (accelerometry) 7) breath test before, during and after fasting to evaluate fatty acid oxidation

—

Countries

Germany

Contacts

Public ContactFranziska Grundler

Klinik Buchinger Wilhelmi GmbH

franziska.grundler@buchinger-wilhelmi.com07551 807 835

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026