Determination of Drugs in Dental Material

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00011148

Enrollment

Registered

2016-10-11

Start date

2017-04-13

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healty subjects and Patients with regular ongoing medication e.g. analgesics

Interventions

Group 1: Intra-oral sample holders with enamel and dentin pellets are treated with solutions of model substances (Amphetamine, Methamphetamine, MDMA, MDA, MDE, Cocaine, Benzoylecgonine, Morphine, Code

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Health subjects: -Age: 18-50 -healthy subject as evaluated by the investigator -women: at least one established method of contraception -sound or restored dentiton -given written informed consent Subjects under medication: -Age: 18-50 -classified as of reduced but stable general heath, assessed by the responsible specialist for addiction medicine and by the investigator -women: at least one established method of contraception -sound or restored dentiton -given written informed consent -constant consumption of an individual amount of methadone or pain drug prescribed by the responsible specialist (for addiction medicine) (other drugs, reported by the responsible specialist for addiction medicine and the subject will be logged in the patients file)

Exclusion criteria

Exclusion criteria: -women: pregnant or breast feeding -withdrawal of informed consent -known allergies against used dental materials -dention not sound or current dental treatment except emergency treatment -intake of drugs that interfere with the detection of the test substances -participation in another clinical trail within the last 30 days -intake of antibiotics within the last 2 months

Design outcomes

Primary

Measure	Time frame
Quantification of drugs (model substances: (Amphetamine, Methamphetamine, MDMA, MDA, MDE, Cocaine, Benzoylecgonine, Morphine, Codeine, Monoacetylmorphine) in dentin and enamel samples on intraoral sample holders by LC-MS/MS after a single simulated consumption or after 5 days, 2 and 4 weeks of treatment of the samples with a drug solution. Quantification of drugs in dentin and enamel samples on intraoral sample holders or prostheses by LC-MS/MS after regular drug intake	—

Measure

Time frame

Quantification of drugs (model substances: (Amphetamine, Methamphetamine, MDMA, MDA, MDE, Cocaine, Benzoylecgonine, Morphine, Codeine, Monoacetylmorphine) in dentin and enamel samples on intraoral sample holders by LC-MS/MS after a single simulated consumption or after 5 days, 2 and 4 weeks of treatment of the samples with a drug solution. Quantification of drugs in dentin and enamel samples on intraoral sample holders or prostheses by LC-MS/MS after regular drug intake

—

Secondary

Measure	Time frame
Determination of drugs (=model substances) in dentin and enamel samples on intraoral sample holders by LC-MS/MS after a single simulated consumption or after 5 days, 2 and 4 weeks of treatment of the samples with a drug solution. Determination of drugs in dentin and enamel samples on intraoral sample holders by LC-MS/MS after regular drug intake	—

Countries

Germany

Contacts

Public ContactMarkus Altenburger

Klinik für Zahneraltungskunde und ParodontologieDepartment für Zahn-, Mund- und KieferheilkundeUniversitätsklinikum Freiburg

markus.altenburger@uniklinik-freiburg.de+49 761 270 49570

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026